Ibuprofen and other NSAIDS rarely affect the liver. Unlike acetaminophen ( Tylenol ), most NSAIDs are absorbed completely and undergo negligible liver metabolism. In other words, the way NSAIDs are metabolized makes liver toxicity (aka. hepatotoxicity) very rare. Tylenol and Advil are both metabolized in the liver, broken down into non-toxic products and then excreted by the kidneys through urine. Dosage The adult dose for Advil is around 200mg to 800mg per dose, a maximum of four times a day. Yes, naproxen, like all NSAIDs, is filtered by the kidneys and liver. Overdosing on NSAIDs can cause itching and fluid retention, which signals kidney and liver problems. HealthBoards Kidney-Liver-Urinary Kidney Disorders kidney damage from taking ibuprofen Tylenol filters through your liver. All drugs have side effects,even those. Tylenol is is tylenol filtered through the kidneys or liver eliminated through the liver. Kidney disease related to analgesics is preventable. Does it harm or strain your kidneys/liver to filter excess water. Filtered through. The liver and the kidneys clear toxins and chemicals from the body. However, some medications can affect the function of these organs. The Hospice website notes that nonprescription analgesic drugs such as ibuprofen can cause or worsen problems in the liver and kidneys. Many analgesics should not be used if there is decreased kidney function, because they reduce the blood flow to the kidney. Also, long term use with higher doses may harm normal kidneys. Acetaminophen is one of the most commonly used medications so you should know if it hurts your liver or kidneys. The short answer: acetaminophen is safe on the kidneys and may damage your liver, but only at high doses. The kidney does not get filtered. It does the filtering of the blood that passes through it. It removes impurities from the blood, and filters these impurities to the urinary … bladder. Re: tylenol vs ibuprofen Typically taking too much tylenol can cause liver damage so never use more than what is recommended. Ibuprofen usually causes stomach problems but it is filtered thru the kidneys and too much could potentially harm them. Important correction: Excedrin does NOT contain any Ibuprofen. Excedrin is made up of Aspirin, Acetaminophen (e.g., Tylenol), and caffeine. The original question is confusing, because Ibuprofen (e.g., Advil) like other NSAIDs are for the most part NOT processed by the liver.